Originally posted by CBB_Fan
View Post
Ryan Anderson is a conservative political philosopher, not a doctor or scientist. He is best known for his work against gay marriage, with a previous book being cited in a dissenting opinion on United States v. Windsor. Anderson's primary argument in either case is that sex is purely concerned with reproduction, which is an opinion for better or worse.
As far as his scientific and biology credits are concerned, from the quoted snippet I do not believe he has done his research. There are a few genes we now understand that are responsible for sexual development in humans: SRY, SOX9, RSPO1/WNT4, FOXL2, and so on. Some of these are on sex chromosomes, while others are on other chromosomes but only activate in response to genes that should be present in the appropriate sex.
SRY is the primary driver of 'masculine' development and is initiated by SOX9, which isn't on a sex chromosome. Usually, a positive feedback loop happens when both are expressed which drives the development of testes and other masculine features in embryonic development. SOX9 is also noted for being a driver of metastatic cancer in adults. Several major disorders of sexual development occur when SRY doesn't function normally, namely Swyer Syndrome when it fails to function in XY individuals and XX Male syndrome when it translocates to the X chromosome.
RSPO1 and WNT4 help drive female embryonic development on the other hand. An absence of WNT4 is also required for male development. If an XY individual has WNT4 and no FGC9, a full sex reversal occurs. WNT4 is found on chromosome 1 and has many other functions outside female sexual development. RSPO1 is also found on chromosome 1, and genetic disorders involving it can result in the masculinization of female individuals even without SRY issues.
I bring this up because from a scientific standpoint the only 'real' differentiator between male and female are the sex chromosomes, the genes involved in sexual development, and the gonads. But none of those is a total binary. Moreover, it isn't as simple as saying that changes merely affect outward appearance. Gonadal tissues can spontaneously shift from ovary to teste when a single gene stops functioning (FOXL2), long after embryonic development; this can be artificially done in a lab. Similarly, there are many factors involved that can go awry in embryonic development after conception.
This has little to do with transgender individuals, but I think it is important to address whether or not Ryan Anderson has the proper understanding of the scientific principles behind the subject. At the very least, it does not appear that he incorporated modern research in embryonic development into his book.
As far as his scientific and biology credits are concerned, from the quoted snippet I do not believe he has done his research. There are a few genes we now understand that are responsible for sexual development in humans: SRY, SOX9, RSPO1/WNT4, FOXL2, and so on. Some of these are on sex chromosomes, while others are on other chromosomes but only activate in response to genes that should be present in the appropriate sex.
SRY is the primary driver of 'masculine' development and is initiated by SOX9, which isn't on a sex chromosome. Usually, a positive feedback loop happens when both are expressed which drives the development of testes and other masculine features in embryonic development. SOX9 is also noted for being a driver of metastatic cancer in adults. Several major disorders of sexual development occur when SRY doesn't function normally, namely Swyer Syndrome when it fails to function in XY individuals and XX Male syndrome when it translocates to the X chromosome.
RSPO1 and WNT4 help drive female embryonic development on the other hand. An absence of WNT4 is also required for male development. If an XY individual has WNT4 and no FGC9, a full sex reversal occurs. WNT4 is found on chromosome 1 and has many other functions outside female sexual development. RSPO1 is also found on chromosome 1, and genetic disorders involving it can result in the masculinization of female individuals even without SRY issues.
I bring this up because from a scientific standpoint the only 'real' differentiator between male and female are the sex chromosomes, the genes involved in sexual development, and the gonads. But none of those is a total binary. Moreover, it isn't as simple as saying that changes merely affect outward appearance. Gonadal tissues can spontaneously shift from ovary to teste when a single gene stops functioning (FOXL2), long after embryonic development; this can be artificially done in a lab. Similarly, there are many factors involved that can go awry in embryonic development after conception.
This has little to do with transgender individuals, but I think it is important to address whether or not Ryan Anderson has the proper understanding of the scientific principles behind the subject. At the very least, it does not appear that he incorporated modern research in embryonic development into his book.
Leave a comment: